Clinical Training

  • Fellowship

    Rhinology, Endoscopic Sinus and Skull Base Surgery
    Massachusetts Eye and Ear Infirmary/Harvard Medical School

  • Residency

    Otolaryngology–Head and Neck Surgery
    Massachusetts Eye and Ear Infirmary/Harvard Medical School

  • Internship

    General Surgery

    Brigham and Women's Hospital/Harvard Medical School

Education

  • M.D., Medical Degree

    Johns Hopkins University
    Baltimore, MD

  • Ph.D. in Immunology

    Johns Hopkins University
    Baltimore, MD

  • B.S. in Biomedical Engineering

    Summa cum laude, Valedictorian

    Columbia University
    New York, NY

Information Sheets

Frequently Asked Questions

  • I have made an appointment to be seen as a new patient—what can I expect?

    Please view our information sheet for new patients. If you have further questions, please call the office at 617-573-6011.

  • I was just diagnosed with chronic rhinosinusitis, what can I expect?

    Please view our general information sheet on chronic rhinosinusitis.

  • I will be having surgery, what do I need to do beforehand?

    Instructions for before surgery can be found on the first page of the surgical information sheet.

  • I just had surgery, what can I expect?

    Expectations for the post-operative period can be found on the second page of the surgical information sheet.

Actively Enrolling Studies

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    Pathophysiology of Inflammatory Sinonasal Disease

    We are actively enrolling participants who are undergoing endoscopic sinus surgery at the Massachusetts Eye and Ear Infirmary and Beth Israel Deaconess Medical Center in Boston.

    This study seeks to identify and characterize the inflammation that exists in patients undergoing endoscopic sinus surgery. The findings of this study will directly contribute to our understanding of how the immune system works in the nose and sinuses, and how the immune system can pathologically change to cause inflammatory sinus diseases like chronic rhinosinusitis. If you are having endoscopic sinus surgery at the Massachusetts Eye and Ear Infirmary or Beth Israel Deaconess Medical Center, and you are interested in learning more, please email me at ahmad.r.sedaghat@gmail.com.

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Orbital Decompression in the Endoscopic Age: The Modified Inferomedial Orbital Strut

Yao WC, Sedaghat AR, Yadav P, Fay A, Metson R.
Endoscopic sinus surgery Otolaryngol Head Neck Surg. 2016 May;154(5):963-9.

Antibiotic prescription for acute rhinosinusitis: Emergency departments versus primary care providers

Bergmark RW, Sedaghat AR.
Health disparities Laryngoscope. 2016 Apr 14.

Aeroallergen sensitivities and development of chronic rhinosinusitis in thirteen adults who initially had allergic rhinitis.

Sedaghat AR, Gray ST, Phillips KM, Caradonna DS.
Chronic rhinosinusitis Allergy Clin Otolaryngol. 2016 Mar 4.

Endoscopic endonasal orbital cavernous hemangioma resection: global experience in techniques and outcomes.

Bleier BS, Castelnuovo P, Battaglia P, Turri-Zanoni M, Dallan I, Metson R, Sedaghat AR, Stefko ST, Gardner PA, Snyderman CH, Nogueira JF, Ramakrishnan VR, Muscatello L, Lenzi R, Freitag S.
Endoscopic sinus surgery Int Forum Allergy Rhinol. 2016 Feb;6(2):156-61.

Endoscopic sinus surgery for chronic rhinosinusitis in patients previously treated for sinonasal malignancy.

Gray ST, Sadow PM, Lin DT, Sedaghat AR.
Endoscopic sinus surgery Laryngoscope. 2016 Feb;126(2):304-15.

Trends in Inpatient Pediatric Polysomnography for Laryngomalacia and Craniofacial Anomalies.

Tawfik KO, Sedaghat AR, Ishman SL.
Ann Otol Rhinol Laryngol. 2016 Jan;125(1):82-9.

Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma.

Sedaghat AR, Matsui EC, Baxi SN, Bollinger ME, Miller R, Perzanowski M, Phipatanakul W.
Allergy J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):82-8.

Socioeconomic determinants of overnight and weekend emergency department use for acute rhinosinusitis.

Bergmark RW, Ishman SL, Scangas GA, Cunningham MJ, Sedaghat AR.
Health disparities Laryngoscope. 2015 Nov;125(11):2441-6.

Emergency department presentation for uncomplicated acute rhinosinusitis is associated with poor access to healthcare.

Scangas GA, Ishman SL, Bergmark RW, Cunningham MJ, Sedaghat AR.
Health disparities Laryngoscope. 2015 Oct;125(10):2253-8.

Impact of day of week on outcomes of endoscopic sinus surgery for chronic rhinosinusitis.

Sedaghat AR, Metson R, Gray ST.
Endoscopic sinus surgery Am J Rhinol Allergy. 2015 Sep-Oct;29(5):378-82.

Immediate and Delayed Complications Following Endoscopic Skull Base Surgery.

Naunheim MR, Sedaghat AR, Lin DT, Bleier BS, Holbrook EH, Curry WT, Gray ST.
Endoscopic sinus surgery J Neurol Surg B Skull Base. 2015 Sep;76(5):390-6.

A Rare Finding of Schwannoma of the Vidian Canal: A Case Report.

Yamasaki A, Sedaghat AR, Lin GC, Curry WT, Shih HA, Gray ST.
J Neurol Surg Rep. 2015 Jul;76(1):e48-51.

Insurance status and quality of outpatient care for uncomplicated acute rhinosinusitis.

Bergmark RW, Ishman SL, Scangas GA, Cunningham MJ, Sedaghat AR.
Health disparities JAMA Otolaryngol Head Neck Surg. 2015 Jun;141(6):505-11.

Volumetric analysis of chronic maxillary atelectasis.

Lin GC, Sedaghat AR, Bleier BS, Holbrook EH, Busaba NY, Yoon MK, Gray ST.
Am J Rhinol Allergy. 2015 May-Jun;29(3):166-9.

Clustering of chronic rhinosinusitis symptomatology reveals novel associations with objective clinical and demographic characteristics.

Sedaghat AR, Gray ST, Caradonna SD, Caradonna DS.
Chronic rhinosinusitis Allergy Am J Rhinol Allergy. 2015 Mar-Apr;29(2):100-5.

Radiographic evaluation of nasal septal deviation from computed tomography correlates poorly with physical exam findings.

Sedaghat AR, Kieff DA, Bergmark RW, Cunnane ME, Busaba NY.
Health economics Int Forum Allergy Rhinol. 2015 Mar;5(3):258-62.

Removal of a wire brush bristle from the hypopharynx using suspension, microscope, and fluoroscopy.

Naunheim MR, Dedmon MM, Mori MC, Sedaghat AR, Dowdall JR.
Case Rep Otolaryngol. 2015;2015:925873.

In response to preapproval of sinus computed tomography for otolaryngologic evaluation of chronic rhinosinusitis does not save health care costs.

Sedaghat AR, Gray ST, Kieff DA.
Health economics Laryngoscope. 2014 Dec;124(12):E471-2.

Objective radiographic density measurements of sinus opacities are not strong predictors of noninvasive fungal disease.

Killeen DE, Sedaghat AR, Cunnane ME, Gray ST.
Chronic rhinosinusitis Am J Rhinol Allergy. 2014 Nov-Dec;28(6):483-6.

Socioeconomic disparities in the presentation of acute bacterial sinusitis complications in children.

Sedaghat AR, Wilke CO, Cunningham MJ, Ishman SL.
Health disparities Laryngoscope. 2014 Jul;124(7):1700-6.

Long-term control of viral replication in a Group O, human immunodeficiency virus type 1-infected individual.

Buckheit RW 3rd, Sexauer SB, Sedaghat AR, Wilke CO, Laeyendecker O, Basseth CR, Blankson JN.
AIDS Res Hum Retroviruses. 2014 Jun;30(6):511-3.

Characterization of tree allergy prevalence in children younger than 4 years.

Sedaghat AR, Sheehan WJ, Bharmanee A, Harris K, Phipatanakul W.
Allergy Ann Allergy Asthma Immunol. 2014 Apr;112(4):388-9.

Prevalence of and associations with allergic rhinitis in children with chronic rhinosinusitis.

Sedaghat AR, Phipatanakul W, Cunningham MJ.
Pediatric chronic rhinosinusitis Allergy Int J Pediatr Otorhinolaryngol. 2014 Feb;78(2):343-7.

Preapproval of sinus computed tomography for otolaryngologic evaluation of chronic rhinosinusitis does not save health care costs.

Sedaghat AR, Gray ST, Kieff DA.
Health economics Laryngoscope. 2014 Feb;124(2):373-7.

Characterization of aeroallergen sensitivities in children with allergic rhinitis and chronic rhinosinusitis.

Sedaghat AR, Phipatanakul W, Cunningham MJ.
Pediatric chronic rhinosinusitis Allergy Allergy Rhinol (Providence). 2014 Jan;5(3):143-5.

Connexin 32 and 43 mutations: do they play a role in chronic rhinosinusitis?

Sedaghat AR, Cunningham MJ, Busaba NY.
Chronic rhinosinusitis Am J Otolaryngol. 2014 Jan-Feb;35(1):33-6.

Regional and socioeconomic disparities in emergency department use of radiographic imaging for acute pediatric sinusitis.

Sedaghat AR, Cunningham MJ, Busaba NY.
Health disparities Am J Rhinol Allergy. 2014 Jan-Feb;28(1):23-8.

Atopy and the development of chronic rhinosinusitis in children with allergic rhinitis.

Sedaghat AR, Phipatanakul W, Cunningham MJ.
Pediatric chronic rhinosinusitis Allergy J Allergy Clin Immunol Pract. 2013 Nov-Dec;1(6):689-91.e1-2.

Sinonasal anatomic variants and asthma are associated with faster development of chronic rhinosinusitis in patients with allergic rhinitis.

Sedaghat AR, Gray ST, Chambers KJ, Wilke CO, Caradonna DS.
Chronic rhinosinusitis Allergy Int Forum Allergy Rhinol. 2013 Sep;3(9):755-61.

Nasal obstruction and anosmia.

Chambers KJ, Sedaghat AR, Roberts DS, Caradonna DS.
JAMA Otolaryngol Head Neck Surg. 2013 Aug 1;139(8):851-2.

Clinical assessment is an accurate predictor of which patients will need septoplasty.

Sedaghat AR, Busaba NY, Cunningham MJ, Kieff DA.
Health economics Laryngoscope. 2013 Jan;123(1):48-52.

Radiographic density profiles link frontal and anterior ethmoid sinuses behavior in chronic rhinosinusitis.

Sedaghat AR, Bhattacharyya N.
Chronic rhinosinusitis Int Forum Allergy Rhinol. 2012 Nov;2(6):496-500.

Risk factors for development of chronic rhinosinusitis in patients with allergic rhinitis.

Sedaghat AR, Gray ST, Wilke CO, Caradonna DS.
Chronic rhinosinusitis Allergy Int Forum Allergy Rhinol. 2012 Sep-Oct;2(5):370-5.

Chronic rhinosinusitis symptoms and computed tomography staging: improved correlation by incorporating radiographic density.

Sedaghat AR, Bhattacharyya N.
Chronic rhinosinusitis Int Forum Allergy Rhinol. 2012 Sep-Oct;2(5):386-91.

Radiology quiz case 3. Malleus fixation.

Ginat DT, Sedaghat AR, Robson CD, Whittemore KR.
Arch Otolaryngol Head Neck Surg. 2012 Aug;138(8):775-6.

A case-control comparison of lingual tonsillar size in children with and without Down syndrome.

Sedaghat AR, Flax-Goldenberg RB, Gayler BW, Capone GT, Ishman SL.
Laryngoscope. 2012 May;122(5):1165-9.

Characterization of obstructive sleep apnea before and after tongue-lip adhesion in children with micrognathia.

Sedaghat AR, Anderson IC, McGinley BM, Rossberg MI, Redett RJ, Ishman SL.
Cleft Palate Craniofac J. 2012 Jan;49(1):21-6.

Does balloon catheter sinuplasty have a role in the surgical management of pediatric sinus disease?

Sedaghat AR, Cunningham MJ.
Pediatric chronic rhinosinusitis Endoscopic sinus surgery Laryngoscope. 2011 Oct;121(10):2053-4.

Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy.

Sedaghat AR, Wilke CO.
Biol Direct. 2011 Sep 12;6:42.

Radiology quiz case 2. Pediatric base of tongue thyroglossal duct cyst (TGDC).

Sedaghat AR, Gallagher TQ, Sadow PM, Cunnane ME, Cunningham MJ.
Arch Otolaryngol Head Neck Surg. 2011 Sep;137(9):955, 956-7.

Prevalence and severity of obstructive sleep apnea and snoring in infants with Pierre Robin sequence.

Anderson IC, Sedaghat AR, McGinley BM, Redett RJ, Boss EF, Ishman SL.
Cleft Palate Craniofac J. 2011 Sep;48(5):614-8.

A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs.

Shen L, Rabi SA, Sedaghat AR, Shan L, Lai J, Xing S, Siliciano RF.
Sci Transl Med. 2011 Jul 13;3(91):91ra63.

Short communication: dynamic constraints on the second phase compartment of HIV-infected cells.

Spivak AM, Rabi SA, McMahon MA, Shan L, Sedaghat AR, Wilke CO, Siliciano RF.
AIDS Res Hum Retroviruses. 2011 Jul;27(7):759-61.

T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors.

Sedaghat AR, Rastegar DA, O'Connell KA, Dinoso JB, Wilke CO, Blankson JN.
Clin Infect Dis. 2009 Dec 1;49(11):1763-6.

Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy.

Brennan TP, Woods JO, Sedaghat AR, Siliciano JD, Siliciano RF, Wilke CO.
J Virol. 2009 Sep;83(17):8470-81.

Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas.

Sedaghat AR, Zhang Z, Begum S, Palermo R, Best S, Ulmer KM, Levine M, Zinreich E, Messing BP, Gold D, Wu AA, Niparko KJ, Kowalski J, Hirata RM, Saunders JR, Westra WH, Pai SI.
Laryngoscope. 2009 Aug;119(8):1542-9.

Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir.

Sedaghat AR, Siliciano RF, Wilke CO.
Antivir Ther. 2009;14(2):263-71.

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs.

Shen L, Peterson S, Sedaghat AR, McMahon MA, Callender M, Zhang H, Zhou Y, Pitt E, Anderson KS, Acosta EP, Siliciano RF.
Nat Med. 2008 Jul;14(7):762-6.

Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle.

Sedaghat AR, Dinoso JB, Shen L, Wilke CO, Siliciano RF.
Proc Natl Acad Sci USA. 2008 Mar 25;105(12):4832-7.

Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics.

Sedaghat AR, German J, Teslovich TM, Cofrancesco J Jr, Jie CC, Talbot CC Jr, Siliciano RF.
J Virol. 2008 Feb;82(4):1870-83.

Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART.

Sedaghat AR, Siliciano RF, Wilke CO.
BMC Infect Dis. 2008 Jan 2;8:2.

Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection.

Chase AJ, Sedaghat AR, German JR, Gama L, Zink MC, Clements JE, Siliciano RF.
J Virol. 2007 Dec;81(23):12748-57.

Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART.

Sedaghat AR, Siliciano JD, Brennan TP, Wilke CO, Siliciano RF.
PLoS Pathog. 2007 Aug 31;3(8):e122.

Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells.

Bailey JR, Sedaghat AR, Kieffer T, Brennan T, Lee PK, Wind-Rotolo M, Haggerty CM, Kamireddi AR, Liu Y, Lee J, Persaud D, Gallant JE, Cofrancesco J Jr, Quinn TC, Wilke CO, Ray SC, Siliciano JD, Nettles RE, Siliciano RF.
J Virol. 2006 Jul;80(13):6441-57.

Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes.

Han Y, Lassen K, Monie D, Sedaghat AR, Shimoji S, Liu X, Pierson TC, Margolick JB, Siliciano RF, Siliciano JD.
J Virol. 2004 Jun;78(12):6122-33.

A mathematical model of metabolic insulin signaling pathways.

Sedaghat AR, Sherman A, Quon MJ.
Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1084-101.

Recent Studies

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    May 30, 2016

    Aeroallergen sensitivities and development of chronic rhinosinusitis in thirteen adults who initially had allergic rhinitis.

    We have previously studied characteristics of adults and children with allergies who go on to develop chronic rhinosinusitis (CRS). We have identified characteristics, such as anatomical factors, that may contribute to the development of CRS in individuals with allergies. Knowledge of these characteristics is important because it helps us to predict which individuals may need more treatment and more frequent monitoring of their allergies to minimize the chances of developing CRS. One question that often arises when discussing whether someone with allergies will develop CRS is whether the number of allergies could contribute. In other words, is someone who is “more allergic” at a higher risk for development of CRS than someone who has fewer allergies?

    In our previous study of children with allergies, we found that the number of allergies was not associated with the development of CRS. We have now found that this same relationship holds in adults as well. Specifically, the number of allergies in adults is not associated with the subsequent development of CRS. These results are important because individuals with many allergies are often the ones who may be most at risk for development of other allergic diseases. However, as far as we can tell, this is not the case for CRS.

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    March 15, 2016

    Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma.

    Allergies occur when there is a specific immunologic reaction, called a hypersensitivity, to a benign substance, called an allergen. The hypersensitivity reaction then causes the symptoms of allergy whenever there is exposure to the corresponding allergen. Allergy is extremely common and especially so in children with asthma.

    In urban environments, there is an increased risk for exposure to certain allergens that may cause hypersensitivity and allergy. This includes primarily mouse and cockroach allergens, which are very common in urban environments like the inner cities. Previous work has shown that mouse and cockroach allergies may be associated with more severe asthma in children living in urban settings. In this study, performed as a part of large multi-center study of asthmatic children in two large metropolitan cities, we sought to find whether nasal allergies were associated with particular allergens. Interestingly, we found that in these asthmatic children living in urban settings, allergy to mouse was associated with having nasal allergies while allergy to other allergens such as cockroach or even more mundane allergens like house dustmite, was not. This study shows that there may be allergens that are most dominant in causing and driving the symptoms of allergies. It is likely that the most dominant allergen is dependent on the setting and it is not surprising that this dominant allergen associated with nasal allergies would be mouse in the inner city where it is extremely common. These findings are meant to better understand which allergies should be most promptly treated and also to help public health efforts to minimize vermin in large cities to reduce nasal allergies in children.

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    March 29, 2015

    Clustering of chronic rhinosinusitis symptomatology reveals novel associations with objective clinical and demographic characteristics.

    Some patients with chronic rhinosinusitis (CRS) may have non-specific ear symptoms such as pressure/pain, fullness or dizziness. In the absence of systemic inflammatory conditions which may affect the ears, often, these patients will be diagnosed with and treated for ear infections when in fact their ears show no obvious evidence of pathology. Other times, no cause may be found, leading to frustration on the part of the patients.

    We have looked at many different types symptoms reported by a large group of CRS patients and have found that "ear symptoms" cluster (and are particularly severe) in association with comorbid allergies. Therefore, CRS patients with allergies also tend to have more common symptoms of ear fullness or pressure as well as dizziness.

    These findings are likely attributable to Eustachian tube dysfunction, which causes symptoms of ear fullness or pressure, in particular during landing when on an airplane. In light of known effects of allergies to cause or worsen Eustachian tube dysfunction as well as the fact that allergies have been associated with inflammation in the middle ear (the space behind the ear drum), our findings 1) provide a reasonable possible mechanism for these troublesome ear symptoms in CRS patients and 2) highlight these symptoms as one sign for when a thorough allergy evaluation should be carried out in CRS patients.

In the Office

I see patients in my clinical office at the Massachusetts Eye and Ear Infirmary Sinus Center.

243 Charles St
Boston, MA 02114

Office phone number: +001 617-573-6011
Fax: +001 617-573-6845